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Description

Each treatment consisted of 15 replicates

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10.1186/s12974-020-1705-z 64

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The composition of immune cell populations as well as their effector functions like pathogen clearance or phagocytosis changes during the process of aging, which is delineated for instance by an increased number of memory T cells compared to nave T cells due to thymus shrinkage, hence the loss of lymphoid tissue [11, 14, 15]

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This integrative perspective supports the notion that persistent disruption of metabolic, immune, and nutritional signaling may sustain the ASD phenotype

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